Comprehensive meta analysis z value download#

When publications involved the same or overlapping data sets, only the study with the largest number of participants was included. Accordingly, abstracts, reviews, and studies in which genotype frequencies were not reported were excluded. Studies were included in the meta-analysis if they satisfied the following inclusion criteria: (1) they evaluated the potential association between the -159C/T polymorphism in the CD14 gene and TB risk, (2) they were case-control studies, (3) genotype distributions were available for cases and controls in order to estimate an odds ratio (OR) with 95% confidence interval (CI) and (4) the distribution of genotypes in the control group was consistent with Hardy-Weinberg equilibrium (HWE). The reference lists of identified studies and review articles were manually searched to find additional relevant publications. Search terms were as follows: вЂњTB or tuberculosisвЂќ in combination with вЂњCD14вЂќ in combination with вЂњpolymorphism or variant or mutationвЂќ. Method 2.1 Literature searchДЄ systematic literature search in Pubmed and Embase databases was performed by two independent reviewers to identify studies examining the possible association between -159C/T polymorphism in the CD14 gene and TB risk on Jan 15, 2013. Since pooled estimates using meta-analysis have proven to be useful in determining the overall risk of certain polymorphisms, the present meta-analysis aimed to clarify the association between the -159C/T polymorphism in the CD14 gene and TB risk. Several studies have investigated whether the -159C/T polymorphism in the CD14 gene is associated with TB risk, and, the results have been inconsistent and inconclusive. As previously shown in genetic studies, a polymorphism in the CD14 proximal promoter, -159C/T (rs2569190), might interact with environmental factors in the development of TB. tuberculosis by mononuclear cells such as macrophages through recognizing components of the cell wall. CD14 contributes to receptor-mediated ingestion of non-opsonised M. The CD14 gene is localized on chromosome 5q31.1 and CD14 is a membrane recognition factor involved in the binding of bacterial components or inhaled endotoxin, which can induce significant lung inflammation and activate immune pathways. Up to now, quite a lot studies have investigated the association between TB susceptibility and genetic variants among which the CD 14 gene has been highlighted. tuberculosis) may explain individual differences in both susceptibility to disease and the course of infection. Recent studies suggest that host genetic factors play critical roles in the pathogenesis and outcome of TB, especially genetic polymorphisms in the immune response to Mycobacterium tuberculosis ( M.

As reported by the latest 2012 global tuberculosis report, in 2011, it is estimated that there were 8.7 million new cases of TB and 1.4 million people died from TB, including almost 1 million deaths among HIV-negative individuals and 430, 000 among people who were HIV-positive. Tuberculosis (TB) is still a public health challenge worldwide. Keywords: Tuberculosis, CD14, Polymorphism, Meta-analysis. To further investigate gene-gene and gene-environment interactions between this polymorphism and tuberculosis risk, more studies are needed. TC+ CC).Д¬onclusion: This meta-analysis suggests that the -159C/T polymorphism in the CD14 gene contributes to tuberculosis susceptibility. Sub-group analysis by ethnicity suggested that the risk of tuberculosis associated with the -159C/T polymorphism was significantly elevated among Asians (odds ratio=1.87 and 95% confidence interval: 1.58-2.21, P<0.05 for TT vs. Combined analysis revealed an obvious association between this polymorphism and tuberculosis risk (odds ratio=1.66 and 95% confidence interval: 1.23-2.25, P<0.05 for TT vs. Results: A total of seven case-control studies involving 3253 subjects (1,574 tuberculosis cases and 1,679 controls) were included. Data were extracted and statistical analysis was performed using Revman 5.1 and STATA 12.0 software.

Methods: We searched in Pubmed and Embase for studies evaluating the association between the -159C/T gene polymorphism and tuberculosis risk.

The present meta-analysis aimed to perform a comprehensive assessment of the literature on the possible association between the -159C/T polymorphism and tuberculosis risk. File import instruction AbstractД«ackground: The -159C/T polymorphism in the CD14 gene has been implicated in susceptibility to tuberculosis, but the results were inconclusive. Select the file that you have just downloaded and select import option Reference Manager (RIS).

Comprehensive meta analysis z value download#

Available fromД¬lick on Go to download the file. The -159C/T Polymorphism in the CD14 Gene and Tuberculosis Risk: A Meta-Analysis. Wang T, Shen Y, Chen L, Guo S, Jia L, Yang T, An J, Wen F.